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Acetaminophen is metabolized while in the liver by way of cytochrome P450 microsomal enzyme. About 8085% with the acetaminophen in the human body is conjugated principally with glucuronic acid also to a lesser extent with sulfuric acid and cysteine. Right after hepatic conjugation, ninety to one hundred% of your drug is recovered inside the urine w

Early signs and symptoms pursuing a potentially hepatotoxic overdose may perhaps contain: nausea, vomiting, diaphoresis, and common malaise. Medical and laboratory evidence of hepatic toxicity might not be clear until forty eight to 72 several hours submit-ingestion.When this medication is used for many years, it may not do the job likewise. Talk w